Sestrin2 prevents age‐related intolerance to ischemia and reperfusion injury by modulating substrate metabolism
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Ferritin Prevents Ischemia Reperfusion Injury
Heme oxygenase-1 (HO-1) is induced under a variety of pro-oxidant conditions such as those associated with ischemia reperfusion injury (IRI) of transplanted organs. HO-1 cleaves the heme porphyrin ring releasing Fe, which induces the expression of the Fe sequestering protein ferritin. By limiting the ability of Fe to participate in the generation of free radicals through the Fenton reaction, fe...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2017
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.201700063r